Abdominal metastases led to death 7 months later. 2 - 4 Visual acuity improved to 20/25 OD after surgery. Cutaneous melanoma rarely metastasizes to the eye. Immune checkpoint inhibitors (ICBs) and targeted therapies have dramatically improved outcomes in patients with cancer, but many patients do not benefit. A capsulorhexis specimen obtained during cataract surgery revealed melanoma deposits ( Figure, B) and established the true cause of pseudouveitis, namely, intraocular metastases from cutaneous melanoma. Use Check Point Capsule Docs to ensure documents are encrypted and secure wherever they are stored. Multiple pigmented deposits were visualized on the right anterior lens capsule and iris ( Figure, A). Check Point Capsule Docs is a solution for protecting and sharing documents securely. 1 The patient’s chronic bilateral iritis led to posterior subcapsular cataracts, which decreased visual acuity to 20/80 OD and 20/50 OS. Checkpoint inhibitors are increasingly used to treat cutaneous melanoma, and these medications can cause uveitis. He was receiving pembrolizumab, a systemic checkpoint inhibitor. Treatment included topical corticosteroids however, low-grade cellularity persisted, and iritis developed in the left eye. A 71-year-old man with psoriatic arthritis and stage IV cutaneous melanoma presented with iritis in the right eye.
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